Chromosomal abnormalities are a major cause of failure of embryos to implant and of miscarriages. Normal healthy human embryos have 23 pairs of chromosomes. In cases of chromosomal abnormalities there may be excess or less number of chromosomes than normal. PGS enables detecting such abnormalities that may be present in the genes.
PGS is advised for couples where a woman’s age is more than 35 years as they have a higher risk of having a baby with chromosomal abnormalities, in cases of history of chromosomal problems or recurrent miscarriages, or if a couple had undergone several unsuccessful IVF cycles.
Besides, it is also possible to remove cells/ blastomeres from day 2/ day 3 embryos; however, PGS done with blastocyst stage leads to more accurate results.
There are some risks that come along with the use of PGS; Embryos are very fragile due to which the procedure of cell removal may damage the embryos; there may not be any normal embryo leading to no embryo available for transfer, screening of embryos has accuracy of approximately 95-96% so there is still a small risk of miscarriage after PGS.
At the same time, PGS has many advantages. The implantation of most viable embryos can help improve implantation rates, reduce spontaneous abortion and enable single embryo transfers, thereby decreasing the risk of multiple pregnancies.
Let us know how we can help.