Preimplantation genetic diagnosis (PGD) is a procedure used prior to implantation to help identify genetic defects within embryos. This serves to prevent certain genetic diseases or disorders from being passed on to the child. The embryos used in PGD are usually created during the process of in vitro fertilization (IVF)
PGD is recommended to couples are at risk of transmitting a known genetic abnormality to their children.Only health and normal embryos are transferred, thereby decreasing the risk of transmitting mutated gene.
Primary candidates for PGD
Conditions diagnosed using PGD
PGD should be offered for 3 major groups of disease:
The PGD test cycle is explained to prospective parents as it involves multiple steps.
Each PGD test is custom- designed on the specific disease and mutation that is inherited in a family. The proband or couples genetic test results will be reviewd and the case accepted if PGD is possible. DNA samples from the couples as well additional family members like parents or affected child will be required. This proces will take 4-5 weeks
2. Stimulation of ovaries
3. Egg collection
5. Culture and Biopsy
6. PGD testing
7. Embryo transfer
Positive Results: Affected Embryos which carries the mutated genes, embryos are not recommended to transfer
Negative Results: Non affected Embryos which doesnot carries the mutated gene, embryos are recommended to transfer.
Most of the risks invloved in PGD treatment are similar to those for conventional IVF which invloves: